Description
Product Characteristics:
Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.
Subcellular location: Nucleus
Synonyms: CBY, arb1, PGEA1, C22orf2, PIGEA14, PIGEA-14, HS508I15A, Protein chibby homolog 1, ARPP-binding protein, Cytosolic leucine-rich protein, PKD2 interactor, Golgi and endoplasmic reticulum-associated 1, CBY1, HRIHFB2025
Target Information: Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]